Indoleamine 2,3-dioxygenase 1 (IDO1) is a 41-42 kD intracellular enzyme that regulates the immune system by catabolizing tryptophan into kynurenine (1). IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response (2). IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival (3, 4). IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immunotherapy (5, 6, 7). IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines (8). IDO is involved in cancer, chronic viral disease, autoimmune disease, allergy and other immune disorders. Emerging evidence also suggests a role for IDO in modulating inflammation, Alzheimer's disease, infectious disease, as well as blood pressure and lipid management.
Amino acids 78-184 of human IDO1 fused to GST
Source Antibody/Purification Information
Mouse monoclonal 10.1 to IDO1, isotype IgG3
Protein G column purified
Species Cross Reactivity
Western, IP, IHC (formalin-fixed paraffin-embedded sections), ELISA
Recommended Dilutions for Each Application
Western - use at an assay dependent dilution
Immunoprecipitation - use at an assay dependent dilution
Immunohistochemistry - use at an assay dependent dilution
To Place an Order
By Phone: 484-476-3474
By Fax: 484-476-8533
By Email: email@example.com
LIMR Development, Inc.
Attn: J. Wynne
100 East Lancaster Avenue
Wynnewood, PA 19096
- Purchase Order (P.O.) - for those accounts in good standing only; net 30 days
- Check/Cash - in advance of shipment
Please have the following information ready when placing an order using a P.O., check, or cash payment:
- Contact Information (please include an email for order status notification)
- Shipping and Billing Information
- P.O. Number or Check Number
- W-9 (new customers only)*
- Credit References Letter (new customers only)*
*Will be used to determine if a credit account may be opened.
Antibody shipment is via Federal Express Standard Overnight, Monday-Thursday in the contiguous United States and Monday-Wednesday in Alaska, Hawaii, and internationally. Antibodies will not be shipped on a holiday or on the day prior to a holiday.
Shipping costs can be charged directly to your Federal Express account number. If you choose to do so, please provide your account number with your shipping address.